Coordinator of the popular committees, Salah Khawaja, said they attempted to enter Jerusalem but were prevented from doing so by Israeli forces, who deployed heavily in the area.
Israeli forces used live fire, tear gas canisters, stun grenades and rubber-coated steel bullets to disperse the march.
Dozens of Palestinian activists also gathered near the village of Hizma carrying Palestinian flags and shouting slogans in support of Jerusalem.
Several youths were injured as Israeli forces opened fire at them to prevent them crossing the checkpoint. The activists managed to close the road, with Israeli forces preventing settlers from traveling to the area.
Dozens of activists also demonstrated by the entrance to Maale Adumim settlement waving Palestinian flags.
“They attempted to detain us for carrying Palestinian flags,” Khawaja said. “What we did today was to emphasize that we do not have a choice but popular resistance and clashing with Israel is a part of our fight to stop Israeli crimes against Palestinians”
An Israeli army spokeswoman said there was an “attempt” to cross the wall, without providing further details.